Active Playthrough (Clicking) Strategy
This strategy is intended for the active player, although it can also be used to increase general idle damage. The core of this strategy is to increase the amount of damage gained by actively clicking the wall, and how to spend your resources in the most effective way to boost overall click damage.
The game starts
Ignore all upgrades except for punchers (this will be the main form of damage and cash generation throughout the game). Increase Punchers to level 50, buying all upgrades along the way, then proceed to increase all other buildings to level 50, one at a time, so as to unlock each one's level 50 upgrade (The level 50 upgrade affects hand punch damage by a percentage equal to the amount of each particular building owned. I.E. 50 clubbers = +50% to hand damage, so on and so forth). Once this has been accomplished, buy all other upgrades to increase general idle damage. When purchasing buildings, only do so with the intent of unlocking the next tier upgrade. Do not buy the cheapest upgrade available solely to increase damage immeadiately; you will end up spending more resources doing so (For example, clubber level 51 is cheaper than puncher level 98, but it will cost you more in the long run to upgrade clubber now instead of reaching the puncher upgrade at level 100 and then buying clubber level 51; $5 for a clubber level is cheaper than $45 for a puncher level, but $8,900 until the next clubber upgrade is more expensive than $3,600 for the next puncher upgrade).
Resetting
As of version 2.3, each wall you destroy grants you cosmic knowledge (later walls give more than earlier walls). When you reset ("rewind time"), your cosmic knowledge is converted into future knowlege capsules. Possessing certain numbers of future knowledge capsules unlocks various trophies.
Resetting removes all of your buildings and resources (except the ones under "Prestige"?), but not your achievements or most of your upgrades. Any upgrades you had unlocked but not yet bought will stay unlocked. You will start on the first wall again, but because you still have almost all of your upgrades, the first few walls should pass very quickly.
Resetting does remove two upgrades: Time Rewinders and Black Research. These upgrades will unlock at the normal time, but you will need to purchase them again. You will also not be able to purchase Black Obliterators before you purchase Black Research, just like in the first run, but since you will keep the other research-related upgrades, you will be able to buy the other buildings from the moment you reset.
Earlier versions used Prestige Coins, and you got the same number from each wall destroyed.